SYNTHESIS OF INTERNAL ACETYLENE ALCOHOLS BASED ON THE SONOGASHIRA REACTION OF TERMINAL ACETYLENE ALCOHOLS AND BENZOLCHLORIDE

Authors

Guzal K. OTAMUKHAMEDOVA, Chirchik State Pedagogical University, Chirchik, UzbekistanFollow
Odiljon E. ZIYADULLAYEV, Chirchik State Pedagogical University, Chirchik, Uzbekistan; Academy of the Ministry of Emergency Situations, Tashkent, UzbekistanFollow
Abduvahob IKRAMOV, Tashkent Institute of Chemical Technology, Tashkent, UzbekistanFollow
Sarvinoz I. TIRKASHEVA, Jizzakh State Pedagogical University, Jizzakh, UzbekistanFollow

DOI

10.34920/cce202415

Abstract

The purpose of the study is to develop a new catalytic system for the synthesis of internal acetylene alcohols from the Sonogastric coupling reaction of terminal acetylene alcohols and benzolchloride. For the first time in this work, internal acetylene alcohols have been synthesized based on reactions of some terminal acetylene alcohols – 3,4-dimethylpentin-1-ol-3, 3,4,4-trimethylpentin-1-ol-3, 1-ethynylcyclohexanol-1, 2-ethynyladamantanol-2, 2-phenylbutin-3-ol-2, 2-(naphthyl-2)butyn-3-ol-2, 2-(furanyl-2)butyn-3-ol-2 and 2-(pyridinyl-4)butyn-3-ol-2 with chloridebenzene. In order to achieve high product productivity in the Sonogashira reaction, alternative conditions have been identified by studying the molar ratios, spatial structure, induction effects of substituents, solvent and catalyst nature, as well as temperature, reaction duration effects, and the reaction mechanism has been proposed on the basis of literature sources.

Recommended Citation

OTAMUKHAMEDOVA, Guzal K.; ZIYADULLAYEV, Odiljon E.; IKRAMOV, Abduvahob; and TIRKASHEVA, Sarvinoz I. () "SYNTHESIS OF INTERNAL ACETYLENE ALCOHOLS BASED ON THE SONOGASHIRA REACTION OF TERMINAL ACETYLENE ALCOHOLS AND BENZOLCHLORIDE," CHEMISTRY AND CHEMICAL ENGINEERING: Vol. 2024: No. 1, Article 5.
DOI: 10.34920/cce202415
Available at: https://cce.researchcommons.org/journal/vol2024/iss1/5