Abstract
The purpose of the research is to develop a method of synthesizing new acetylene diols, to determine their structure, physico-chemical properties and to create optimal conditions by studying the effect of various environments on product yield. For the first time, nucleophilic coupling reactions of 1-ethynylcyclohexanol with some ketones - cyclohexanone, acetophenone, para-chloroacetophenone, adamantanone, methylhexylketone and ethyl-n-butyl ketones were studied using the Bu4NOH/DMSO/H2O catalytic system. New acetylene diols – 1-(2-(1-hydro-xycyclohexyl)ethynyl)cyclohexanol (1), 1-(3-hydroxy-3-phenylbut-1-ynyl)cyclohexanol (2), 1-(3-(4-chlorophenyl)-3-hydroxybut-1-ynyl)cyclo-hexanol(3), 1-(2-(1-hydroxyadamantanyl)-ethynyl)cyclohexanol (4), 1-(3-hydroxy-3-methyldec-1-ynyl)cyclohexanol(5) and 1-(3-ethyl-3-hydroxyhept-1-ynyl)cyclohexanol (6) were synthesized in the process. The effects of the catalyst for the synthesis of acetylene diols, the nature of the solvent, the mole ratio of the starting materials, the temperature, and the duration of the reaction were systematically analyzed. The composition, structure and purity of the synthesized acetylene diols were determined by modern physical and chemical research methods.
Recommended Citation
TIRKASHEVA, Sarvinoz; ZIYADULLAEV, Odiljon; IKRAMOV, Abduvahob; and BURIEV, Forxod
(2024)
"1-ETINILSIKLOGEKSANOLNING AYRIM KETONLAR BILAN TETRABUTILAMMONIY GIDROKSID YORDAMIDA ENANTIOSELEKTIV ALKINILLANISH ASOSIDA ATSETILEN DIOLLAR SINTEZI,"
CHEMISTRY AND CHEMICAL ENGINEERING: Vol. 2022:
No.
3, Article 7.
DOI: https://doi.org/10.34920/cce202237
Available at:
https://cce.researchcommons.org/journal/vol2022/iss3/7